“As a consequence, novel vaccination strategies have to be developed to overcome immune imprinting by ancestral #SARSCoV2 antigen.”
https://t.co/SXqqvydKlE
Assessment of hybrid immunity, boosters, bivalent vs BQ.1.1 and BA.2.75.2 (pseudovirus assay)
@TheLancetInfDis https://t.co/BRK4bhUFfg— Eric Topol (@EricTopol)
Dec 6, 2022
from http://twitter.com/EricTopol
No need to dream anymore. This can be done.
But it takes will, priority and funding
And debunking the delusion that we’re done with #SARSCoV2
https://t.co/TrR777xZTI
https://t.co/eKHGg7EPtM https://t.co/1ijx5gN79W— Eric Topol (@EricTopol)
Nov 20, 2022
from http://twitter.com/EricTopol
My review of the BQ.1.1 variant, on its path to dominance in the United States and many countries in Europe.
The first #SARSCoV2 variant with a marked increase in immune evasion not to have induced a wave.
https://t.co/DqMJ7LAALu— Eric Topol (@EricTopol)
Nov 19, 2022
from http://twitter.com/EricTopol
Knock ’em all out.
Discovery by @EmoryVaccineCtr of a broadly neutralizing antibody (bnAb) vs all #SARSCoV2 variants through BA.5. Could be used alone or in combo w/ other bnAbs to make a variant-proof vaccine
https://t.co/r3YDB1FOB0 @ScienceAdvances @SanjeevKumar_01 https://t.co/nUWf21gUuX— Eric Topol (@EricTopol)
Oct 5, 2022
from http://twitter.com/EricTopol
The #SARSCoV2 sewer sleuths
It’s one thing to track the burden of variants in wastewater; it’s another to trace one to a specific office with <30 employees
https://t.co/RmnEaWJZQz
@nature by @ewencallaway w/ phenomenal detective work by @SolidEvidence @dho https://t.co/ngLGuxRIJ1— Eric Topol (@EricTopol)
Sep 26, 2022
from http://twitter.com/EricTopol
New US #SARSCoV2 genomic surveillance data
The proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1
https://t.co/jjl2AnOYb5 https://t.co/FUSgl3CAR0— Eric Topol (@EricTopol)
Sep 23, 2022
from http://twitter.com/EricTopol
Why is obesity an important risk factor for severe Covid?
@ScienceTM, a potential contributing factor
#SARSCoV2 infects fat cells –> local and systemic inflammation
https://t.co/sOUkNG63DJ
Possible that fat cells may be a 🦠reservoir and increase risk of #LongCovid https://t.co/96mYZ0wXyP— Eric Topol (@EricTopol)
Sep 22, 2022
from http://twitter.com/EricTopol
We went from sequence of #SARSCoV2 to highly effective vaccines in 10 months, which was unprecedented. But nearly 2 years later, we see no replication of such hyper-accelerated effort, despite remarkable advances in science
Today @ScienceTM yet another
https://t.co/aQCjw2Z30o https://t.co/BmbD7aDjWg— Eric Topol (@EricTopol)
Aug 17, 2022
from http://twitter.com/EricTopol
The first study to use microneedle patch blood collection of antibodies to #SARSCoV2 (via remote, site-less, home collection) shows higher levels induced for 3 shots of Moderna (N=378) vs Pfizer (N=476) vaccines for all variants including Omicron BA.1
https://t.co/isXzQSXDyt https://t.co/EYesfIfIoA— Eric Topol (@EricTopol)
Aug 2, 2022
from http://twitter.com/EricTopol
The length of time of infectiousness of #SARSCoV2
https://t.co/IB2yW3wMjT
“There is no data to support 5 days or anything shorter than ten days [of isolation].”
Paxlovid rebound may extend that further— Eric Topol (@EricTopol)
Jul 26, 2022
from http://twitter.com/EricTopol
We continue to largely ignore the importance of #SARSCoV2’s effect on interferons, blocking innate immunity, our 1st line of defense against the virus, as a key component of its immune evasion. Here is a new @PNASNews report that pinpoints a mechanism.
https://t.co/IvAzyXW05d https://t.co/WisQ8EPhm0— Eric Topol (@EricTopol)
Jul 25, 2022
from http://twitter.com/EricTopol
The #SARSCoV2 infection imprinting problem
https://t.co/PE4QjMv69U
new @ScienceMagazine by @BoytonRosemary @Daltmann10 @imperialcollege and colleagues https://t.co/fZYaTcWYv2— Eric Topol (@EricTopol)
Jul 14, 2022
from http://twitter.com/EricTopol
Today @TheLancetInfDis
If you want to see what more #SARSCoV2 immune escape looks like, new BA.4/5 data for vaccination response and monoclonal antibody resistance
https://t.co/OA6kDmNJNs https://t.co/a1VzehzARb— Eric Topol (@EricTopol)
Jun 28, 2022
from http://twitter.com/EricTopol
When it comes to #SARSCoV2 and Covid, it’s important to keep your eyes on the ball. The ball is BA.5 and here is what we know about it
https://t.co/vwK1ZXsU7m https://t.co/qaH1eTdqPO— Eric Topol (@EricTopol)
Jun 28, 2022
from http://twitter.com/EricTopol
Just about every week there is a new, broad neutralizing antibody (bnAb) discovery, like this one, that is variant-proof and would take down all #SARSCoV2, that vaccines could be made to induce, that we’re not advancing
https://t.co/ektcfd0NEN @ScienceTM https://t.co/01xhPBANj2— Eric Topol (@EricTopol)
May 25, 2022
from http://twitter.com/EricTopol
Co-infection of BA.1 and BA.2, detected by random sampling
“underlines the need for effective genomic surveillance to reduce the risk of generating #SARSCoV2 recombinants with novel pathogenic and immunologic properties”
https://t.co/EnBrXYQhYI https://t.co/e64Clrh73O— Eric Topol (@EricTopol)
May 25, 2022
from http://twitter.com/EricTopol
Why do certain monoclonal antibodies to the ancestral #SARSCoV2 cross-react to Omicron?
Importance of the receptor-binding domain-2 (RBD-2) region
New @SciImmunology
https://t.co/TnrVS6e4tI https://t.co/eQouLNHgXy— Eric Topol (@EricTopol)
May 10, 2022
from http://twitter.com/EricTopol
We are climbing a ladder of #SARSCoV2 increased infectiousness with booster shots not working as well or as long, with the illusion that the pandemic is over. It’s not and there’s much we can and should do to get ahead of it
https://t.co/SoWDo6ownt— Eric Topol (@EricTopol)
May 5, 2022
from http://twitter.com/EricTopol
Can antibodies to #SARSCoV2 be transferred from an immune to non-immune host by aerosol?
https://t.co/74Uqfwt4Ny— Eric Topol (@EricTopol)
May 1, 2022
from http://twitter.com/EricTopol
Watching—South Africa🇿🇦 may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. 🇫🇷sees early uptick too.
https://t.co/PzkGIE5mJd https://t.co/3upTRtwtbb— Eric Feigl-Ding (@DrEricDing)
Apr 4, 2022
from http://twitter.com/DrEricDing
It would be better to not see all these #SARSCoV2 recombinants cropping up, even if one hasn’t led to significant spread yet
Another one: BA.1/BA.2 just reported in 2 people arriving to Hong Kong
https://t.co/0s8BQzmuA4 https://t.co/1FJ9q6Ybgf— Eric Topol (@EricTopol)
Apr 3, 2022
from http://twitter.com/EricTopol
When Covid myocarditis occurs, #SARSCoV2 infected heart muscle cells are quite rare; it’s mainly due to inflammation. But pacemaker cells may exhibit a different pattern of infection susceptibility and auto-destruction https://t.co/GyQlnXcuka @CircRes https://t.co/TB0y9nVzqW
— Eric Topol (@EricTopol)
Apr 1, 2022
from http://twitter.com/EricTopol
The quest to get our germinal centers armed vs #SARSCoV2, providing durable humoral immunity
https://t.co/hM6wY6fo16 @CellCellPress multiple advantages of vaccination over NI, by @stutangye @GarvanInstitute @Row_Bull @KirbyInstitute https://t.co/9Dqe3jWeHs— Eric Topol (@EricTopol)
Mar 19, 2022
from http://twitter.com/EricTopol
Hello 🇺🇸
You just got over a wave of the most transmissible #SARSCoV2 variant the world has seen, with the highest level of hospitalizations in the pandemic.
Now you are facing a variant w/ 30% more transmissibility, w/o mitigation measures, low vaxx coverage, and gutting funding https://t.co/6zRjH9h02U— Eric Topol (@EricTopol)
Mar 17, 2022
from http://twitter.com/EricTopol
Anyone who thinks they can predict what properties the #OmicronVarient of #SARSCoV2 will have just by looking at the genome sequence is wrong. If we could do that, we would not have to do experiments. Amino acid changes have different effects when paired with other changes! https://t.co/5Ivyu8oLjq
— Vincent Racaniello (@profvrr)
Dec 3, 2021
from http://twitter.com/profvrr
On the latest #TWiV the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against #SARSCoV2 infection one year after mRNA-1273 vaccination of nonhuman primates https://t.co/q9dugrwvZW https://t.co/XAiLZ9Od1s
— Vincent Racaniello (@profvrr)
Oct 31, 2021
from http://twitter.com/profvrr
📌UK study: ~1 in 4 people who were infected & tested PCR positive for COVID19 did NOT go on to develop IgG antibodies. Particularly if they were asymptomatic & elderly.
Want a sure way to develop antibodies against #SARSCoV2? Get vaccinated💉!
Report: https://t.co/l03exSATVI https://t.co/G5d4mdwgKV
— Dr. Ali Nouri (@AliNouriPhD)
Oct 30, 2021
from http://twitter.com/AliNouriPhD
Clearance of #SARSCoV2 for post-vaccination Covid in health care workers who were symptomatic was 11 days (mean) compared to those without symptoms of only 1 day
https://t.co/bST6bgR4n9 @AnnalsofIM https://t.co/BmErb9Zn0r— Eric Topol (@EricTopol)
Oct 25, 2021
from http://twitter.com/EricTopol
Is it time from vaccination or Delta that drives waning of 💉effectiveness?
New @TheLancet study ~3.4 million @Pfizer vaccinated individuals @KPSCalResearch, with a subgroup of their #SARSCoV2 sequenced, shows persistent waning of effectiveness vs infections across variants /1 https://t.co/H8a4qCnbI2— Eric Topol (@EricTopol)
Oct 4, 2021
from http://twitter.com/EricTopol
On the origin of #SARSCoV2, the @institutpasteur has found “closest known relative” with some sequence homology of the receptor binding domain (and other loci) in bats from Laos
https://t.co/UUrklxYvSd
https://t.co/0R8ooSbn1v
@edwardcholmes https://t.co/wEN1K9z6pR— Eric Topol (@EricTopol)
Sep 24, 2021
from http://twitter.com/EricTopol